>>3262935No, because in that case there's no buffer between reality and fantasy. There's no plausible deniability to trick your brain into disassociating the real person's real self versus who they pretend to be in front of the cameras. With an anime avatar, there is. Ever hear of the idiom "what the eyes can't see the heart doesn't grieve over"? It applies here in both directions.
Maybe if you're so inclined, persistent and lucky enough you could track down the twitch thot you like and hook up with her.
But even if you do it to your oshi's roommate(good luck considering half of them seem to be socially recluse neets), it's not going to be the same. It shouldn't be the same.