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Even if Zen's a man irl, using his real voice would be far better than text to speech, since using tts really limits gameplay and reaction time.
And it's not like a male voice with a female avatar hasn't been successful before; one of the earlier vtubers was Kitsunemusume Youtuber Ojisan, a guy who got over 180K subs with his real voice and kitsune girl avatar. He even got a couple of figurines and a Nendo. Makes me wonder when the Holo's are going to get there inevitable Nendoroid figures, since they're all significantly more popular than ojisan.