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I mean, if you think about it, the very idea of Vtubbing is similar to Lain. A feminine being on the net that young males worship and around which people form communities? Yeah, pretty much the same thing.
Anyway, this one has been mentioned various times already, but here goes: Amemori Sayo, maybe, is the closest thing to an actual Lain. Better not be a filthy EOP, though, if you wanna watch her.