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I haven't watched much Pippa recently but I don't believe she would be purposefully malicious towards Ami, sure there's her being awkward as hell and pipkins but once she sees how Ami wears her heart on her sleeves and how earnest she is she would probably try to tone down any weird shit with her and just have a nice stream where they enjoy their niche interests
but maybe I'm being too optimistic and most of my exposure to Pippa have been with Tenma collabs