>>81121267>It matters for how long it keeps you alert and how much you need to consume throughout the day.>Yeah, and tolerance work by adjusting your adenosine production upwards, so you need to block more bindings if you regularly douse yourself in higher concentrations of caffeine.The effect over time is defined by the AUC, not by the duration of full clearance as this doesn't take into account the threshold of activity, even if first-order kinetics occur. The effect will still be of a higher degree even if downmodulation occurs, or at least that's our consensus in big pharma. The main problem would be toxicity, that as you say, happens to some people. Pic related for AUC.
Still, I'm gonna admit that I'm shitting up the thread, so I'm gonna stop and go drink my green tea. As CC says, have a nice morning(?), anon.
>>81122476I wouldn't really worry about that, anon, any reputable vendor (at least in Europe) analyzes their batches for any kind of contamination. It would appear in their CoAs.
