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It's a very common phenomenon for larger internet personalities to say that they genuinely have no friends because they either become jaded and think every interaction as potential content, see everyone who reaches out to them as wanting something in return, or push others away because others don't fit their idea of an actual friend, see: bigger youtubers, meta chasing youtubers, big >twitch streamers, etc
It's not out of the question that Gura, whose previous life started on Twitch, genuinely feels that way. Just because two personalities make content together often, doesn't always translate to actual friendship.