>>67340761several VTubers have autism that they openly stated
it's not a deterring factor people who enjoy your stuff will stick around, there is no such thing as universal appeal, nor something universally unappealing
just don't try to start streaming to an empty room
people who grew quickly after starting to stream either had some social boost like an established creator associating with them or made some other content before to garner an already existing audience like Lucy Pyre in pic related for example having made YouTube videos for a while before her first stream
so in short no, mental issues and conditions are not a deterrent, there are multiple autistic vtubers. hell some are even psychotic, having talked about the medication they are taking to stay stable
your audience will find you once you start, the complicated thing is making content
several VTubers including Lucy attribute getting the inspiration to having actually started making content to this song:
https://youtu.be/_M-6lkoi6L4?si=1bZb5_qc8ZlvliKvso it might work as motivation
vtubers from the top of my head with the condition are Haruka from VShojo and Lucy who is considered a large indie by /lig/, and I'm forgetting a lot of people