I did some tests with
https://github.com/SkyTNT/anime-segmentationI used a mixture of AI generated images, screenshots of vtuber streams, and a random manga crop I had lying around. Results are pretty mixed, but it seems to do pretty well on some images. The results are't 100% perfect, but they're usually good enough that they'll only require very basic touching up in a paint program.
https://catbox.moe/c/xddvmq