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Cass went with ten strength. You can get by a lot easier with ten strength. Wouldn't be surprised if Cass did some studying before starting. Many weapons have a strength requirement, and ten strength opens your options. As the game progresses though you are going to want to specialize at something. I'm going to make a prediction that (judging by her community size, and the recent relevance of the show) I'll take a guess that Cass will choose to combat the legion, and probably use shotguns. That'll probably be late game. In the beginning like every new player she'll probably hoard a variety of weapons with the Swiss army knife logic of tool for the job. If she is able to wise up though Cass will probably main a singular weapon. I'd like to see her use the super sledge just because that is a fallout weapon of all time, costs no ammo, and has a cool name. I think cass will probably end up with shotguns though. Shotguns are tempting because the variety of ammo, and perks specialized for shotguns specifically.
It's been awhile, but I think Kson went with Machete, and plasma weapons. Henya went with the 10mm (probably because it's a starting weapon). End game if Cass is to reach end game I'm thinking shotguns. I doubt she can comprehend the value of melee, and unarmed, and shotguns are beloved weapons to many. Once again variety. Variety is the spice of life, and there is a decent variety of shotguns, and ammunitions for the shotguns.