Lui is uncanny. Her streaming persona is just a normal everyday person, which clashes with the fantastical nature of her avatar. I think L2D is a debuff, and being a regular everyday 3DPD streamer would suit her more. Even if she's not a looker, I assume she can still exercise and wear a mask. Unless she really drew a bad lottery ticket, in which case I suppose it can't be helped.
Regardless, I believe Vtubers are at their best when the streamer is being a tongue in cheek chuuni and playing a character. If a vtuber isn't going to play along with kayfabe then being a vtuber is just a waste. As a point of fact, not every person is a good fit for any given medium.