Just spotted a manga about a guy's classmate roping him into becoming her VTuber mama (VTuberはママならない). And then there was that urban fantasy manga a while back where an abandoned VTuber avatar came to life as a tsukumogami. Or that comedy where the protag's dad is not-Kizuna Ai.

Any interesting stories you've seen with VTubers as a plot element?

There's one yuki-onna myth that /vp/ is talking about a lot right now, and I kind of want to see a modern retelling. A guy confesses to his wife of many years how he once had a crush on a yuki-onna VTuber, and his wife yells "That was me, you fuck! I had to graduate because of you!"