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Every EN holomem is a coded reference to the cyclical apocalypse that happens due to Disaster (is my preferred name for it; cultures throughout history have called it Saturn, Odin, and Yaldabaoth, among many others).
Calli is the simplest symbol of Disaster: death. It is a destroyer, as feared as it is venerated.
Death is (or was for some time) also the object of affection for Kiara, a phoenix, which represents a violent death and rebirth. Disaster comes and kills many, but not all, meaning a rebirth for the whole planet.
Ina is the opposing version of the same concept, being modeled after Cthulhu. It comes to kill, but those it leaves alive are driven to madness, reinforcing the reset point for humanity.
Gura being from Atlantis is a direct reference to the first empire, during the Golden Age of Humanity. The story survives, in tales and ruins, waiting for people to decode.
Ame is also an opposite to Gura: she is the portion of humanity that escapes the worst of Disaster's wrath, symbolized by being a time traveler.
Which brings me to EN2 and Kronii, the "Warden of Time." Disaster, for us, is the real Warden of Time, thanks to its gravity.
Of course, time is nothing without space, and vice versa, which we see represented with Sana.
Disaster brings with it chaos, where we find Bae, the "little sister of Calli (death)," her hair as red as the sky under Disaster's influence.
Nature itself holds one of the many keys to surviving Disaster, which brings us to Fauna, a female representation of the mythological Green Man; her surname, Ceres, being a direct reference to the goddess of nature and fertility.
Time and nature battle over Mumei, the guardian of civilization, her short attention span representing the history lost after the havoc wrought by Disaster.
Finally, we reach my personal favorite: IRyS, under neither generation, but the sole member of Project HOPE, as in the Hope that the tale of Disaster will renew the planet and our species to survive it.