>>2012201like most of the site, just make sure that when you modify an element in a specific page (for example the home page) it won't affect others elements in others pages (such as the watch page/channel/etc).
the script I'm currently using is around 1200 lines, I didn't really modify the structure of yt itself (the boxes are in the same position as before), only transformed the header into a sidebar, it wasn't that difficult, plus contraty to Google, Youtube rarely modify its source code.