>>1480810>Ping Pong the Animation>Serial Experiments Lain>Perfect BlueBased on these three, I'd recommend Kuuchuu Buranko. It showcases the struggles of psychiatry patients and how their illnesses impact their lives.
Much like PPTA, the art style is quite unconventional but executed quite effectively. Although it's a different sort of unconventional, if you can tolerate PPTA's art style, I think you'll enjoy Kuuchuu Buranko as well.