>>656369Rurouni Kenshin. Japan was changing after the shogun era and samurais became errand vagabonds, this anime tells the story of many such individuals.
Fullmetal Alchemist ORIGINAL (+ Conqueror of Shambala). The original series depicts a version of its own, a tale of tragedy and powers beyond our science, our dreams, and our nightmares.
Cardcaptor Sakura. The magical girl that inherits a zodiac of powers, also has to catch them all before they run rampant.
Sailor Moon. Main character is the reincarnation of a moon princess, battles the forces that killed her while trying to maintain a personal life.
Slayers. In a world ruled by magic, Rina Inverse is a traveling wizard looking for fame and fortune, then he met Gaudi, who possess an incredible weapon, and some very powerful enemies.
Yu Yu Hakusho. A student killed in a car accident is given a second chance, he must stop supernatural entities breaking into our world, but the an ever increasing powerful groups are more than a challenge.
Sola. Between romance and drama this can be quite sad and shocking about a boy and a girl, can't ell you much without spoilers but the supernatural part plays a role of getting in between the story of its characters.
Robotech (the saga by Harmony Gold). Epic space opera, consider watching the Harmony Gold version, there is so much going on for particular characters who are part of a major event but never for a minute you lose grip of love story or the action. With the invasion of aliens the only hope for mankind is an alien ship that crash landed years ago.
Saint Seiya. The legendary saga of Athena and her warriors is a cosmic fight here on earth. Mystical powers and a good plot is a classic you must not miss.