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SEL acknowledges and deal with several topics in psychology, including escapism, reality, conciousness and communication. Its profound and abstract focus on these topics make the viewer relate to an analogously deep level, while other viewers may find the series boring or weird.
Its completely logical for us here to share many psychological traits, like the desire to escape or disappear from our responsibilites, or the unavoidable feeling of nothingness and lack of purpose.
Lain, if a metaphor, unifies us exemplifying many of these concepts and sensations. As we relate to her (even up to the point of idealization), we are relating to each other.
A shrink would be glad to analyze this beautiful niche little group of autists.