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Go on any velomobile forum and you'll read countless threads about tyres, and the need for a much tougher tyre on the hard shoulder side as it constantly picks up glass, metal shards and wire, since you shouldn't really ride these right down the centre of a road (unless you have rather large testicles). I really wouldn't want to try to control a tiller steered cumb with a blown front wheel downhill
I've also read a fair few threads about riders wiping out on normal roads because they coasted onto the rumble strips at speed and lost control and flew into a ditch
They're also prone to dying, since they have all the same mechanical vulnerability as a bike (admittedly with less exposure to elements and less impacts) but with often experimental frames and slightly bodged steering systems, really long drive and brake systems and a whole host of niche parts (chains have to be DIY'd out of many bike chains for instance), and you're not gonna find parts for a 3 wheel hub or 72 tooth chainring in some small town.
They are incredible feats of human powered travel and aesthetic as fuck, but a two wheeled recumbent with an aero luggage box and well designed fairing gets you pretty close for much less weight and downsides
