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I have a GRX front/rear, new cassette (Deore Cs Hg50 11-36), new chain (KMC 10 speed). I had that same cassette in the past, but now when I shift into the second to last gear, it skips a lot. Only on that one gear.
Could it be RD allignment? My older cassette worked just fine; this one cog was sepparate from the rest, maybe I forgot to do some step when installing the cassette?