I have two different sized Lowepro Flipsides (500 and 300 I think), and they both can fit my a7iii+Tamron 150-500 AND my tripod inside. I still have some vertical space on both so they should fit your huge 180-600.
I use the larger one for hikes, and the smaller one I use for general travel. Outdoors, I have the weather cover on all the time so I can just place the bag down even on damp surfaces (wet soil, sandy beaches) and still have access to my gear as the Flipside opens at the back.
>>4422294As someone who also rides a bike for long distances and up mountains, I can say that you will absolutely hate having a 5kg weight on your shoulders. And if you're going on trails with uneven terrain, you might fuck up your gear if your bike decides it wants to go horizontal.