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Someone on /k/ described the issues of the Colt Python in a concise yet detailed way, so I'll just post this screencap for reference.
The Colt Anaconda was a more modernized take on the Python, done with much more modernized way of manufacture. It's not perfect either, but overall it's actually a very well put together gun, probably one of the last truly good Colt revolvers.
Though the surface heat treated internals can be an issue for replacing worn out parts, and they're not freely interchangeable or easily swapped between guns, what the Colt Anaconda actually has going for it is that the frame, cylinder, lockup, and forcing cone, are all VERY robust.
The Anaconda was available in two cartridges, .44 Magnum, and .45 Colt, the latter which with modern brass you could hotrod to make loads comparable to off the shelf .44 Magnum loads, and even beyond that, almost approaching the output of .454 Casull, not to talk about particularly high pressure loads of .44 Magnum
Buffalo Bore is a company which makes very powerful ammunition for various cartridges, and for their extra hot loads of .44 Magnum and .45 Colt, they specify among others, the Colt Anaconda as one of the revolvers which are suitable for this sort of power, and warn against loading their ammunition in guns which they don't specifically list by name.