>>95356So Colt does their new take on the Python, they use CNC machining and other modern techniques, and they change some things on the design.
The lockwork is the big part, infamously weak, they completely redesign it, the frame is altered to be stronger to prevent stretching.
I see other changes, though I'm not 100% certain about the reasons for them, I'll note them; the locking recesses on the cylinder are elongated (possibly related to the triggerpull), the extractor star has a distinct triangular shape (which looks pretty cool actually), and the exact shape and spacing of the ventrib on the barrel is altered.