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Here's a Smith & Wesson Model 1917 revolver, the large frame .45 caliber revolver with a .45 Auto chambered cylinder, cut for using half-moon clips and full-moon clips, adopted as a stopgap measure to fill out handgun needs during the first World War.
This one has been altered, the barrel cut down to about 3" with the sight moved to match, along with a pair of Pachmayr rubber grips. The resulting gun is a fairly handy carry gun, not too small, not too big, with the spur and sights intact to enable more fine marksmanship if necessary. It features a 'shoe' on the trigger, giving it wider surface area, making trigger pulls easier and more comfortable, particularly when rapid.
The theoretically best way to carry this would be with .45 Auto-Rim cartridges loaded in the chamber (thus not having to factor in the friction provided by the clip holding the cartridges for extraction), and then have a pair or two of half-moon clips with .45 Auto for quick reloading if needed. Issue would be to find a good matching defensive load of .45 Auto Rim to a good defensive load of .45 Auto, though if one were inclined they could solve that by handloading it all (which allegedly is something targeted by district attorneys if defensive shootings become court cases).
I really like the form-factor of this thing, seems like it would be very comfortable and easy to shoot.