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I've randomized all of the in-game traded Pokémon in Fire Red and once I trade for them I have to use them instead of the crutch Pokémon I started with. So far Nidoran was replaced with a Nosepass, Farfetch'd was replaced by a Wooper, and Nidorina was replaced with a Mankey. I haven't gotten a Poliwhirl to trade for it yet but the Jynx in Cerulean City is replaced by a Venomoth. Once I get Cut I'll find out what Mr. Mime was replaced with.