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Do NOT try to pick up cosplayers at events. Not only are your chances low because of all the attention they are getting, bitches look completely different underneath all of that make-up, not to mention whatever disease she might have picked up from some other con.
What you SHOULD do instead is try to pick up artists that sell merch. You have an easy excuse to approach them, especially if you offer to help them out when they are packing up, they are usually kinkier than those attention whores, are more creative in bed, and are more eager and willing to please you.
Do the right thing - dick down a shy artist that has been repressed sexually for ages. You'll have especially good time if you're into bushy girls.