Guys... remember when Ame felt so bad she had to lie down during a TTRPG stream?
>We showed three case reports of drug hypersensitivity after oral administration of folic acid, but reactions have been reported also after the ingestion of fortified food with very low content of folic acid. In a case report of 2015, Schrijvers et al.,1 in fact, showed the case of anaphylactic shock after intake of folic acid and other drugs in a woman who referred pruritus, flushing, and diarrhea and needed to lie down after ingestion of beverage or food fortified with vitamins and folic acid.
In all the cases of hypersensitivity, the great majority of subjects tolerated folic acid from natural sources. This leads to a speculation that the active principle of folic acid in natural foodstuff may have been rendered non-allergenic by food processing or that the antigens are absent or occult in these products.5 Another hypothesis12 speculates that the dietary folic acids, being the polyglutamate form, had a minor bioavailability.
>needed to lie down after ingestion of beverage or food fortified with vitamins and folic acid.
