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I used to have this as my phone wallpaper, either yotsuba's half or keanu's side depending on how I felt. A couple years ago I was really depressed and had no close friends to talk to about it. Then I discovered 4chan, specifically /b/ (before it became just another shitty porn board), there I spent hours every day and could talk to people in similar situations as mine and help each other cope with it.
When I was out or away from my computer this wallpaper always reminded me that /b/ would be there when I got back home.