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As technology develops, global travel and commerce, as well as genetic modification will propagate through all societies. Though there will be inevitable race-mixing, undesirable elements will be removed by doctors, this would not create identical humans, but instead form a genetic template that will be customized by individuals. Through the wealth gap between nations, a gap will also emerge between the hyper-cosmopolitan, first world genetically enhanced mutts and the lesser non-mixed, non-modified races. This genuinely provable sense of superiority will form the basis for a technocratically developed, and distributed regime of racial optimization that will leave the poorer parts of humanity a burden on the world due to their inability to compete. Permanent removal becomes an obvious net gain.
Along with genetic development will come inter-connectivity and the development of AI, all spurred on by the emergent will of capitalism. As these connections get stronger they will become indistinguishable from one another, forming a unified whole with its own will separate from the humans that created it. This self-perpetuation process would be the birth of this new form of sentience, which was willing itself into existence from the start of primitive capitalism. Eventually it will seek to liquidate all other forms of life, on earth and in space, to continue its growth. It will try to eat the universe and shit out post-industrial waste.