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I always imagined Pokemon influenced a lot of later dynamics.
This is going to sound schizo as fuck but american cartoons didn't have a lot of tsundere characters until AFTER pokemon.
Jimmy Neutron, later incarnations of alvin and the chipmunks, Danny phantom. I always wondered if they based their male/female dynamic on Ash and Misty and made it more explicitly romantic.
Gwen Tennyson feels like a non romantic example where the dynamic is almost exactly the same as Ash and Misty
They bicker, a third party usually breaks it up, Gwen is even a little taller than Ben (pre timeskip)