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Let me explain the difference.
Although they claim not to be, hololive is much more like an "idol company". They hire girls for their talent in a specific field. Like art, singing, voice acting....etc. They also keep the girls away from males, and are basically selling a pseduo-girlfriend experience. The girls are pure seiso virgins, and nobody can say otherwise.
Nijisanji talents are better described as "streamers" instead of "idols". They are not really hired for their talent, but for their ability to put on an entertaining stream. They are also often hired because of their friendship with current Nijisanji talents, thus you get tons of friendship collabs. They don't care about intergender collabs, girls freely stream with males and curse as much as they want. Some of the Japanese streamers are openly married, and talk about their sex habits and such. You'd never see that in Hololive.
The business strategy is also much different. Hololive likes to heavily promote their talents before debut. Building up for months and months, before finally debuting and getting massive numbers of subscribers. They do the same thing for outfit reveals and such, lots of buildup and keeping people waiting, deliberately.
Whereas Nijisanji is much more about volume. Pushing out wave after wave of talents in short succession with only a modest amount of promotion. The Nijisanji boys were announced, and released literally a week later. It's only been like 6 months and Nijisanji already has 15 English livestreamers, while Holoive has taken a full year to release 11 of them.
